Pinnacle offers turn-key wireless and tethered neurophysiological systems for mice and rats, including systems for EEG/EMG, biosensors (glutamate, lactate, and glucose), oxygen sensors, and fast scan cyclic voltammetry. Pinnacle’s neurophysiological systems implement a modular design strategy, allowing the easy addition of new measurement tools to expand the range of experiments possible within a single recording setup. This includes optogenetics, electrical stimulation, synchronized video, accleremeters, and sleep deprivation. A variety of headmount configurations are available to simplify surgery and provide reliable, reproducible, low-noise EEG/EMG connections. The core foundation for the Sirenia Software suite is a free acquisition package with premium modules available to meet advanced analysis requirements. Single- and group-housed cages, lids, food hoppers, stands and illuminators can be added to most Pinnacle systems. Products can be customized to meet research needs.