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Neurotransmitter Analysis using HPLC with Electrochemical Detection. The ALEXYS Neurotransmitter Analyzer has been developed for analysis of brain tissue, fruit fly or microdialysis samples. The ALEXYS is based on UHPLC with electrochemical detection with a couple of unique features to make it suitable for research in neuroscience. First, the system must be suitable for handling small sample volume.Second, the system must have an excellent sensitivity to be able to quantify extremely low concentrations of certain neurotransmitters.Third, in real life samples the detection sensitivity is not the only thing that matters, when it comes to the lowest detectable concentration.
Small sample volume
The system must be suitable for handling small sample volume. This is especially important for microdialysis samples. Typical flow rates in microdialysis are 1 – 2 µL/min, decreasing the fraction size to a few microliters enables a temporal resolution of a few minutes.
The ALEXYS uses a wall jet flow cell with adjustable spacing, the SenCell. Detection limits down to 20 pmol/L for dopamine, serotonin and noradrenaline have been reported (0.1 fmole).
Brands: DECADE Elite Electrochemical Detection
Sencell wall jet flow cell
ALEXYS Neurotransmitter Analyzer